Mark-Us: A Function Annotation Server for Protein Structures

Mark-Us is a web server to assist the assessment of the biochemical function for a given protein structure.

Mark-Us identifies related protein structures and sequences, detects protein cavities, and calculates the surface electrostatic potentials and amino acid conservation profile.

The results can be browsed by an interactive web interface that allows to integrate Gene Ontology terms, UniProt features, and the Enzyme Classification.

Start webserver

Click here to launch Mark-Us.


Petrey D, Fischer M, Honig B. Structural relationships among proteins with different global topologies and their implications for function annotation strategies. Proc Natl Acad Sci U S A. 2009 Oct 13;106(41):17377-82.


Mark-Us is supported by a funding from the NIH Grant # GM030518 and GM074958.

Developed in the Honig Lab.


For questions related to Mark-Us, contact